P38 MAPK (phospho Thr180) Antibody
CATALOG NUMBER: 79-218- Clonality: Polyclonal
- Tested Applications: IHC, WB
- Host Species: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Conjugate: Unconjugated
- Size: 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse, Rat
- IMMUNOGEN: P38 MAPK (Phospho-Thr180) antibody was raised against a peptide sequence around phosphorylation site of threonine 180 (E-M-T (p) -G-Y ) derived from Human P38MAPK.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: IHC, WB
- APPLICATION NOTE: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
- SPECIFICITY: This antibody detects endogenous level of P38 MAPK only when phosphorylated at Threonine 180.
- PREDICTED MOLECULAR WEIGHT: 43 kDa
Properties
- PURIFICATION: Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
- CLONALITY: Polyclonal
- PHYSICAL STATE: Liquid
- BUFFER: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: Store antibody at -20°C for up to one year.
Additional Info
- NCBI OFFICIAL SYMBOL: MAPK14
- ADDITIONAL NAMES: RK, p38, CSBP, EXIP, Mxi2, CSBP1, CSBP2, CSPB1, PRKM14, PRKM15, SAPK2A, p38ALPHA, PLC1, MAPK2, MAPKAPK-2, MAPKAPK2
- Protein Accession Number: NP_001306.1
- PROTEIN GI NUMBER: 4503069
- NCBI GENE ID NUMBER: 1432
Background
- Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO mRNA during hypoxic stress. Isoform Mxi2 activation is stimulated by mitogens and oxidative stress and only poorly phosphorylates ELK1 and ATF2. Isoform Exip may play a role in the early onset of apoptosis.
- 1: Kim JE, et al. (2005) J Proteome Res Jul-Aug; 4 (4): 1339-1346Meng F, et al. (2005) Am J Physiol Cell Physiol May 25Jin ZH, et al. (2005) Oncogene Mar 17; 24 (12): 1973-1981
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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