p130 Cas (phospho Tyr410) Antibody
CATALOG NUMBER: 79-783- Clonality: Polyclonal
- Tested Applications: IHC, WB
- Host Species: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Conjugate: Unconjugated
- Size: 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse, Rat
- IMMUNOGEN: p130 Cas (phospho Tyr410) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 410 (G-V-Y (p)-A-V) derived from Human p130 Cas .
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: IHC, WB
- APPLICATION NOTE: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
- SPECIFICITY: The antibody detects endogenous levels of p130 Cas only when phosphorylated at tyrosine 410.
- PREDICTED MOLECULAR WEIGHT: 130 kDa
Properties
- PURIFICATION: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: Store antibody at -20°C for up to one year.
Additional Info
- NCBI OFFICIAL SYMBOL: BCAR1
- ADDITIONAL NAMES: BCAR1, CRKAS, CRK-ASSOCIATED SUBSTRATE
- Protein Accession Number: NP_055382.2
- PROTEIN GI NUMBER: 44662836
- NCBI GENE ID NUMBER: 9564
Background
- Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration. Overexpression confers antiestrogen resistance on breast cancer cells.
- 1: Katarzyna Modzelewska, J. Biol. Chem., Dec 2006; 281: 37527 - 37535.
- 2: Kevin Ogden, Am J Physiol Heart Circ Physiol, Dec 2006; 291: H2857 - H2863.
- 3: Sangkil Nam, Cancer Res., Oct 2005; 65: 9185 - 9189.
- 4: Norikazu Yamana, Mol. Cell. Biol., Sep 2006; 26: 6844 - 6
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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