P-Glycoprotein Antibody
CATALOG NUMBER: 62-130- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- IMMUNOGEN: This P-Glycoprotein (ABCB1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 647-677 amino acids from the Central region of human P-Glycoprotein (ABCB1).
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
- PREDICTED MOLECULAR WEIGHT: 141 kDa
Properties
- PURIFICATION: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: ABCB1
- ADDITIONAL NAMES: Multidrug resistance protein 1, ATP-binding cassette sub-family B member 1, P-glycoprotein 1, CD243, ABCB1, MDR1, PGY1
- Protein Accession Number: P08183
- PROTEIN GI NUMBER: 238054374
- NCBI GENE ID NUMBER: 5243
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- The membrane-associated ABCB1 protein is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. ABCB1 is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
- 1: Saito, S., et al., J. Hum. Genet. 47(1):38-50 (2002). Kerb, R., et al., Pharmacogenomics 2(1):51-64 (2001). Cascorbi, I., et al., Clin. Pharmacol. Ther. 69(3):169-174 (2001). Hoffmeyer, S., et al., Proc. Natl. Acad. Sci. U.S.A. 97(7):3473-3478 (2000). Mickley, L.A., et al., Blood 91(5):1749-1756 (1998).
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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