- Trial Size
NUP155 Antibody
CATALOG NUMBER: 4703- Clonality: Polyclonal
- Tested Applications: ELISA, WB
- Host Species: Rabbit
- Species Reactivity: Human, Mouse
- Conjugate: Unconjugated
- Size: 0.02 mg | 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Rat: (100%)
- IMMUNOGEN: NUP155 antibody was raised against a 18 amino acid synthetic peptide from near the carboxy terminus of human NUP155.
The immunogen is located within the last 50 amino acids of NUP155. - CONJUGATE: Unconjugated
- TESTED APPLICATIONS: ELISA, WB
- APPLICATION NOTE: NUP155 antibody can be used for detection of NUP155 by Western blot at 0.5 - 1 μg/mL.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested. - POSITIVE CONTROL 1: Cat. No. 1286 - P815 Cell Lysate
Properties
- PURIFICATION: NUP155 Antibody is affinity chromatography purified via peptide column.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: NUP155 Antibody is supplied in PBS containing 0.02% sodium azide.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: NUP155 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: NUP155
- ADDITIONAL NAMES: NUP155 Antibody: N155, KIAA0791, Nuclear pore complex protein Nup155, 155 kDa nucleoporin
- Protein Accession Number: NP_705618
- PROTEIN GI NUMBER: 24430149
- NCBI GENE ID NUMBER: 9631
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- NUP155 Antibody: The nuclear pore complex (NPC) is a protein assembly localized at the nuclear rim and mediates macromolecular transport between the nucleus and the cytoplasm. One protein in this assembly is the nucleoporin (NUP)-155, which is localized symmetrically to both the nucleoplasmic and cytoplasmic faces of the NPC. NUP155 has been reported to interact with both NUP35 and the mRNA export factor Gle1, but the functions of these interactions are still unknown. NUP155 has also been shown to be required for NPC assembly and nuclear envelope (NE) membrane fusion. NUP155 is recruited late in NE formation, suggesting that NUP155 defines an essential late step in NE assembly. NUP155 has recently been identified as an HIV dependency factor (HDF), suggesting that NUP155 may be an important drug target in HIV treatment. At least two isoforms of NUP155 are known to exist.
- 1: Tran EJ and Wente SR. Dynamic nuclear pore complex: life on the edge. Cell2006; 125:1041-53.
- 2: Radu A, Blobel G and Wozniak RW. Nup155 is a novel nuclear pore complex protein that contains neither repetitive sequence motifs nor reacts with WGA. J. Cell Biol.1993; 121:1-9.
- 3: Hawryluk-Gara LA, Shibuya EK, and Wozniak RW. Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex. Mol. Biol. Cell2005; 16:2382-94.
- 4: Rayala HJ, Kendirgi F, Barry DM, et al. The mRNA export factor Gle1 interacts with the nuclear pore complex protein Nup155. Mol. Cell Proteomics2004; 3:145-55.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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