NRXN3 Antibody
CATALOG NUMBER: 60-163- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Chicken, Mouse, Rat
- IMMUNOGEN: This NRXN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 436-462 amino acids from the C-terminal region of human NRXN3.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
- PREDICTED MOLECULAR WEIGHT: 69 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: NRXN3
- ADDITIONAL NAMES: Neurexin-3-beta, Neurexin III-beta, Neurexin-3-beta, soluble form, Neurexin-3-beta, C-terminal fragment, NRXN3-CTF, NRXN3, KIAA0743
- Protein Accession Number: Q9HDB5
- PROTEIN GI NUMBER: 218512141
- NCBI GENE ID NUMBER: 9369
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- Neurexins are a family of proteins that function in thevertebrate nervous system as cell adhesion molecules and receptors.They are encoded by several unlinked genes of which two, NRXN1 andNRXN3, are among the largest known human genes. Three of the genes(NRXN1-3) utilize two alternate promoters and include numerousalternatively spliced exons to generate thousands of distinct mRNAtranscripts and protein isoforms. The majority of transcripts areproduced from the upstream promoter and encode alpha-neurexinisoforms; a much smaller number of transcripts are produced fromthe downstream promoter and encode beta-neurexin isoforms. Thealpha-neurexins contain epidermal growth factor-like (EGF-like)sequences and laminin G domains, and have been shown to interactwith neurexophilins. The beta-neurexins lack EGF-like sequences andcontain fewer laminin G domains than alpha-neurexins. [provided byRefSeq].
- 1: Saus, E., et al.Psychiatr Res 44(14):971-978(2010)
- 2: Hotta, K., et al. J. Hum. Genet. (2010) In press :
- 3: Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
- 4: Cirulli, E.T., et al. Eur. J. Hum. Genet. 18(7):815-820(2010)
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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