NME1 Antibody
CATALOG NUMBER: 58-191- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- IMMUNOGEN: This NME1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-57 amino acids from the Central region of human NME1.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
- PREDICTED MOLECULAR WEIGHT: 17 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: NME1
- ADDITIONAL NAMES: Nucleoside diphosphate kinase A, NDK A, NDP kinase A, Granzyme A-activated DNase, GAAD, Metastasis inhibition factor nm23, NM23-H1, Tumor metastatic process-associated protein, NME1, NDPKA, NM23
- Protein Accession Number: P15531
- PROTEIN GI NUMBER: 127981
- NCBI GENE ID NUMBER: 4830
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- This gene (NME1) was identified because of its reducedmRNA transcript levels in highly metastatic cells. Nucleosidediphosphate kinase (NDK) exists as a hexamer composed of 'A'(encoded by this gene) and 'B' (encoded by NME2) isoforms.Mutations in this gene have been identified in aggressiveneuroblastomas. Two transcript variants encoding different isoformshave been found for this gene. Co-transcription of this gene andthe neighboring downstream gene (NME2) generatesnaturally-occurring transcripts (NME1-NME2), which encodes a fusionprotein comprised of sequence sharing identity with each individualgene product.
- 1: Boissan, M., et al. Cancer Res. 70(19):7710-7722(2010)
- 2: Wang, P.H., et al. Gynecol. Oncol. 119(1):70-75(2010)
- 3: Conery, A.R., et al. Proc. Natl. Acad. Sci. U.S.A. 107(35):15461-15466(2010)
- 4: Wang, Z., et al. Med. Sci. Monit. 16 (8), CR357-CR364 (2010) :
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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