NMDAR1 (phospho Ser890) Antibody
CATALOG NUMBER: 79-798- Clonality: Polyclonal
- Tested Applications: IF, IHC
- Host Species: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Conjugate: Unconjugated
- Size: 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse, Rat
- IMMUNOGEN: NMDAR1 (phospho Ser890) antibody was raised against a peptide sequence around phosphorylation site of Serine 890 (A-S-S (p)-F-K) derived from Human NMDAR1.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: IF, IHC
- SPECIFICITY: The antibody detects endogenous levels of NMDAR1 only when phosphorylated at serine 890.
- PREDICTED MOLECULAR WEIGHT: 120 kDa
Properties
- PURIFICATION: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: Store antibody at -20°C for up to one year.
Additional Info
- NCBI OFFICIAL SYMBOL: GRIN1
- ADDITIONAL NAMES: GLURZ1, GRIN1, NMD-R1, NMDZ1, NMZ1
- Protein Accession Number: NP_015566.1
- PROTEIN GI NUMBER: 11496971
- NCBI GENE ID NUMBER: 2902
Background
- NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.
- 1: Guang Bai, J. Biol. Chem., Jan 1998; 273: 1086.
- 2: Guang Bai, J. Biol. Chem., Mar 1995; 270: 7737.
- 3: Mai T. Dang, PNAS, Oct 2006; 103: 15254 - 15259.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
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