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Home / Chemical / Niclosamide
Niclosamide
Niclosamide

Niclosamide

CATALOG NUMBER: 10-033
  • Size: 1 g
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Specifications

  • PREDICTED MOLECULAR WEIGHT: 327.1
  • Formula: C13H8Cl2N2O4
  • CAS: 50-65-7
  • Solubility: Soluble in DMSO (30mg/ml), dimethylformamide or 100% ethanol. Sparingly soluble in water
  • InChi Key: RJMUSRYZPJIFPJ-UHFFFAOYSA-N
  • Smiles: OC1=CC=C(Cl)C=C1C(NC2=CC=C([N+]([O-])=O)C=C2Cl)=O
  • RTECS: VN8400000
  • Merck Index: 5.110416667

Properties

  • PURITY: greater than or equal to 95%
  • PHYSICAL STATE: Lyophilized
  • STORAGE CONDITIONS: Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry.Protect from moisture and oxygen Use/Stability:Stable for at least 2 years after receipt when stored at -20C.

Additional Info

  • ADDITIONAL NAMES: 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide; 2′,5-Dichloro-4′-nitro-salicylanilide; BAY-2353; Bayluscid; Cestoid; HL2447; Yomesan

Background

  • Antihelminthic, molluscicide and trypanocidal agent that inhibits mitochondrial oxidative phosphorylation and anaerobic ATP production. Anticancer agent with antiproliferative activity in a broad spectrum of cancer cells. Targets and inhibits multiple signaling pathways, including STAT3, NF-kB, Wnt/β-catenin, Notch and mTORC1. Shown to block TNF-α-induced IκBα phosphorylation, translocation of p65 and the expression of NF-κB-regulated genes and elevates reactive oxygen species (ROS) levels. Promotes Frizzled1 internalization, down-regulates the expression of Dishevelled-2 protein and inhibits β-catenin stabilization. Inhibits mTORC1 but not mTORC2 signaling in cells maintained in nutrient-rich conditions. Cell permeable selective STAT3 inhibitor (IC50=0.25μM). Inhibits the activation, nuclear translocation and transactivation of STAT3. Selective over STAT1, STAT5, JAK1, JAK2 and Src kinases. Induces cell cycle arrest, growth inhibition, autophagy and apoptosis. Inhibits S100A4 (Metastasin-1)-induced metastasis in vivo. Inhibits androgen receptor (AR) splice variants. Anti-inflammatory compound. Quorum sensing inhibitor. Broad-spectrum antiviral agent that targets acidified endosomes. Has been shown to inhibit replication of SARS and is a potential candidate to treat SARS-CoV-2 (COVID-19) infections. Antiobesity and antidiabetic agent. Positive allosteric neuropetide Y4 receptor ligand and increases energy expenditure and lipid metabolism through mitochondrial uncoupling.

Disclaimer

  • FOR RESEARCH USE ONLY
    For additional information, visit ProSci's Terms & Conditions Page.
  • Disclaimer: This product is for research use only.
Powered by Bioz See more details on Bioz

CATALOG NUMBER: 10-033

  • Size: 1 g
  • List Price: $215.00
Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

Note: Online orders only accepted for shipment within the USA. Click here for the list of international distributors.

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