Mouse Slc5a8 Antibody
CATALOG NUMBER: 60-717- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Mouse
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Mouse
- IMMUNOGEN: This Mouse Slc5a8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 548-574 amino acids from the C-terminal region of mouse Slc5a8.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
- PREDICTED MOLECULAR WEIGHT: 67 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: Slc5a8
- ADDITIONAL NAMES: Sodium-coupled monocarboxylate transporter 1, Electrogenic sodium monocarboxylate cotransporter, Solute carrier family 5 member 8, Slc5a8 {ECO:0000312 | MGI:MGI:2384916}
- Protein Accession Number: Q8BYF6
- NCBI GENE ID NUMBER: 216225
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons.
- 1: Borthakur, A., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 299 (4), G928-G934 (2010) :
- 2: Singh, N., et al. J. Biol. Chem. 285(36):27601-27608(2010)
- 3: Becker, H.M., et al. Am. J. Physiol. Renal Physiol. 299 (1), F141-F154 (2010) :
- 4: Miyauchi, S., et al. Biochim. Biophys. Acta 1798(6):1164-1171(2010)
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
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