Mouse Epha2 Antibody
CATALOG NUMBER: 57-864- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Mouse
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Mouse
- IMMUNOGEN: This Mouse Epha2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-323 amino acids from the Central region of mouse Epha2.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
- PREDICTED MOLECULAR WEIGHT: 109 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: Epha2
- ADDITIONAL NAMES: Ephrin type-A receptor 2, Epithelial cell kinase, Tyrosine-protein kinase receptor ECK, Tyrosine-protein kinase receptor MPK-5, Tyrosine-protein kinase receptor SEK-2, Epha2, Eck, Myk2, Sek2
- Protein Accession Number: Q03145
- NCBI GENE ID NUMBER: 13836
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A3, -A4 and -A5. Induces apoptosis in a TP53/p53-independent, caspase-8-dependent manner (By similarity). Plays an important role in angiogenesis and tumor neovascularization. The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. May function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. May be involved in cell-cell interactions guiding early hindbrain development.
- 1: Islam, S., et al. Dig. Dis. Sci. 55(9):2478-2488(2010)
- 2: Kim, J., et al. Mol. Cell. Biol. 30(7):1582-1592(2010)
- 3: Zirzow, S., et al. Dev. Biol. 336(2):145-155(2009)
- 4: Jun, G., et al. PLoS Genet.(7), E1000584 (2009) :
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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