Specifications
- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Gorilla (100%), chimpanzee (100%), Monkey (92%)
- IMMUNOGEN: Anti-MNDA antibody (9645) was raised against a peptide corresponding to 13 amino acids near the carboxyl terminus of human MNDA. The immunogen is located within the last 50 amino acids of MNDA.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: E, IHC, WB
- APPLICATION NOTE: WB: 1 μg/mL; IHC: 2 μg/mL. Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples. All other applications and species not yet tested.
- POSITIVE CONTROL 1: Cat. No. 1208 - THP-1 Cell Lysate
- PREDICTED MOLECULAR WEIGHT: Predicted: 46kD
Observed: 46 kD
Advanced Validation
- ISOFORMS: Human MNDA has one isoform (407aa, 45.8kD). Mouse MNDA has 2 isoforms, isoform 1 (425aa, 47kD) and isoform 2 (423aa, 46.8kD). Rat MNDA has one isoform (438aa, 49.7kD). 9645 can detect MNDA in human, but not in mouse and rat.
Properties
- PURIFICATION: MNDA Antibody is affinity chromatography purified via peptide column.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: MNDA Antibody is supplied in PBS containing 0.02% sodium azide.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: MNDA antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: MNDA
- ADDITIONAL NAMES: MNDA
- Protein Accession Number: P41218.1
- PROTEIN GI NUMBER: 730038
- NCBI GENE ID NUMBER: 4332
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- MNDA Antibody: MNDA controls the expression of MCL-1 and BCL02 in chronic lymphocytic leukemia cells. MNDA is also a useful marker in the recognition and differential diagnosis of marginal zone lymphomas. MNDA has a role in regulating programmed cell death in myeloid progenitor cells, and its down-regulation in myelodysplastic syndromes is related to granulocyte-macrophage progenitor cell sensitivity to TRAIL-induced programmed cell death.
- 1: Bottari et al. Exp Hematol. 2020; 88:68-82
- 2: Wang et al. Am. J. Clin. Pathol. 2019; 151(3):337-343
- 3: Kanellis et al. Lukemia 2019; 23(10):1847-1857
- 4: Briggs et al. Cancer Res. 2006; 66(9): 4645-4651
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
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