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Home / By Source / Human Cells / MHC Class I-related Protein A Recombinant Protein

MHC Class I-related Protein A Recombinant Protein

CATALOG NUMBER: 92-148
  • Size: 0.05 mg

Specifications

  • SPECIES: Human
  • SOURCE SPECIES: Human Cells
  • RECOMBINANT PROTEIN SEQUENCE: Ala23-Glu308
  • FUSION TAG: C-Fc tag
  • APPLICATION NOTE: This recombinant protein can be used for biological assays. For research use only.
  • PREDICTED MOLECULAR WEIGHT: 59.9 kD

Properties

  • PURITY: Greater than 95% as determined by reducing SDS-PAGE.
    Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.
  • PHYSICAL STATE: Lyophilized
  • BUFFER: Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O.
  • STORAGE CONDITIONS: Lyophilized protein should be stored at -20°C, though stable at room temperature for 3 weeks.
    Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
    Aliquots of reconstituted samples are stable at -20°C for 3 months.

Additional Info

  • NCBI OFFICIAL SYMBOL: MICA
  • ADDITIONAL NAMES: MHC Class I Polypeptide-Related Sequence A, MIC-A, MICA, PERB11.1
  • Protein Accession Number: Q29983
  • PROTEIN GI NUMBER: 767928039
  • NCBI GENE ID NUMBER: 100507436

Background

  • MHC class I polypeptide-related sequence A, also known as MIC-A, PERB11.1 and MICA, is a single-pass type I membrane protein which belongs to the MHC class I family of MIC subfamily. MICA contains one Ig-like C1-type domain and is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by NK cells, NKT cells, and most of the subtypes of T cells. MICA is the ligand for NK cell activating receptor KLRK1/NKG2D. MICA seems to have no role in antigen presentation. MICA leads to cell lysis by binding to KLRK1.

Disclaimer

  • FOR RESEARCH USE ONLY
    For additional information, visit ProSci's Terms & Conditions Page.
  • Disclaimer: Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER: 92-148

  • Size: 0.05 mg
  • List Price: $420.00
Datasheet
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