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Home / By Type / Monoclonal / MET Antibody [F8D4]
MET Antibody [F8D4]
MET Antibody [F8D4]

MET Antibody [F8D4]

CATALOG NUMBER: 13-495
  • Clonality: Monoclonal
  • Tested Applications: IF, IHC, WB
  • Host Species: Mouse
  • Species Reactivity: Human
  • Conjugate: Unconjugated
  • Size: 100 uL

Specifications

  • HOST SPECIES: Mouse
  • SPECIES REACTIVITY: Human
  • IMMUNOGEN: Recombinant protein of human MET
  • CONJUGATE: Unconjugated
  • TESTED APPLICATIONS: IF, IHC, WB
  • APPLICATION NOTE: WB: 1:500 - 1:1000
    IHC: 1:20 - 1:50
    IF: 1:20 - 1:50
  • POSITIVE CONTROL 1: HepG2
  • POSITIVE CONTROL 2: SW620
  • PREDICTED MOLECULAR WEIGHT: Observed: 120kDa

Properties

  • PURIFICATION: Affinity purification
  • CLONALITY: Monoclonal
  • ISOTYPE: IgG
  • PHYSICAL STATE: Liquid
  • BUFFER: PBS with 0.02% sodium azide, pH7.3.
  • STORAGE CONDITIONS: Store at 4°C. Avoid freeze / thaw cycles.

Additional Info

  • NCBI OFFICIAL SYMBOL: MET
  • ADDITIONAL NAMES: MET, AUTS9, C-Met, HGF/SF receptor, HGFR, Met kinase, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, HGF receptor, RCCP2, Tyrosine-protein kinase Met
  • NCBI GENE ID NUMBER: 4233
  • USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background

  • This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers.

Disclaimer

  • FOR RESEARCH USE ONLY
    For additional information, visit ProSci's Terms & Conditions Page.
  • Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER: 13-495

  • Size: 100 uL
  • List Price: $365.00
Datasheet
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