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MER Antibody [7E5G1]
CATALOG NUMBER: 32-192- Clonality: Monoclonal
- Tested Applications: E, WB
- Host Species: Mouse
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 0.1 mL
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- HOST SPECIES: Mouse
- SPECIES REACTIVITY: Human
- IMMUNOGEN: Ni-NTA purified full-length recombinant MER-His expressed in E. Coli strain BL21 (DE3).
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: E, WB
- APPLICATION NOTE: Western Blot:1:500 - 1:2,000
ELISA:Propose dilution 1:10,000.
Determining optimal working dilutions by titration test.
Properties
- CLONALITY: Monoclonal
- ISOTYPE: IgG1
- BUFFER: Ascitic fluid containing 0.03% sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: MER monoclonal antibody can be stored at -20°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: MERTK
- ADDITIONAL NAMES: MER, Proto-oncogene c-MerMER, RP38, c-mer
- Protein Accession Number: Q12866
- PROTEIN GI NUMBER: 160332297
- NCBI GENE ID NUMBER: 10461
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- MER (c-mer proto-oncogene tyrosine kinase) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. MER has been identified as a tyrosine kinase potentially involved in the development of glioblastomas. It is expressed at highest levels in ovary, prostate, lung and kidney. Gas6, a growth arrest specific gene, and the related anticoagulation factor Protein S have been identified as ligands for the UFO family of receptors. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).
- 1: McGough N. Cummings JH. Proc Nutr Soc.2005, Nov,64(4):434-50. Review.
- 2: Allouache D. Gawande SR. Tubiana-Hulin M. et al. BMC Cancer. 2005, Nov 29,5:151.
- 3: Seguineau C. Soudant P. Moal J. et al. Lipids.2005, Sep,40(9): 931-9.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
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