MED17 Antibody
CATALOG NUMBER: 58-351- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- IMMUNOGEN: This MED17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 332-361 amino acids from the Central region of human MED17.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
- PREDICTED MOLECULAR WEIGHT: 73 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: MED17
- ADDITIONAL NAMES: Mediator of RNA polymerase II transcription subunit 17, Activator-recruited cofactor 77 kDa component, ARC77, Cofactor required for Sp1 transcriptional activation subunit 6, CRSP complex subunit 6, Mediator complex subunit 17, Thyroid hormone receptor-associated protein complex 80 kDa component, Trap80, Transcriptional coactivator CRSP77, Vitamin D3 receptor-interacting protein complex 80 kDa component, DRIP80, MED17, ARC77, CRSP6, DRIP77, DRIP80, TRAP80
- Protein Accession Number: Q9NVC6
- PROTEIN GI NUMBER: 296437366
- NCBI GENE ID NUMBER: 9440
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- The activation of gene transcription is a multistepprocess that is triggered by factors that recognize transcriptionalenhancer sites in DNA. These factors work with co-activators todirect transcriptional initiation by the RNA polymerase IIapparatus. The protein encoded by this gene is a subunit of theCRSP (cofactor required for SP1 activation) complex, which, alongwith TFIID, is required for efficient activation by SP1. Thisprotein is also a component of other multisubunit complexes e.g.thyroid hormone receptor-(TR-) associated proteins which interactwith TR and facilitate TR function on DNA templates in conjunctionwith initiation factors and cofactors.
- 1: Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
- 2: Jang, M.K., et al. Mol. Cell 19(4):523-534(2005)
- 3: Tomomori-Sato, C., et al. J. Biol. Chem. 279(7):5846-5851(2004)
- 4: Sato, S., et al. J. Biol. Chem. 278(17):15123-15127(2003)
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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$35 Dry Ice Shipment fee may be required on some items.
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