MAP2K7 (phospho Thr275) Antibody
CATALOG NUMBER: 79-856- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Conjugate: Unconjugated
- Size: 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse, Rat
- IMMUNOGEN: MAP2K7 (phospho Thr275) antibody was raised against a peptide sequence around phosphorylation site of threonine 275 (A-K-T (p)-R-S) derived from Human MAP2K7.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: Western Blot: 1:500~1:1000
- SPECIFICITY: The antibody detects endogenous levels of MAP2K7 only when phosphorylated at threonine 275.
- PREDICTED MOLECULAR WEIGHT: 43 kDa
Properties
- PURIFICATION: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: Store antibody at -20°C for up to one year.
Additional Info
- NCBI OFFICIAL SYMBOL: MAP2K7
- ADDITIONAL NAMES: PRKMK7, JNKK2, MKK7, MAP2K7, MP2K7
- Protein Accession Number: NP_660186.1
- PROTEIN GI NUMBER: 21735544
- NCBI GENE ID NUMBER: 5609
Background
- The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.
- 1: Wu Z.,Mol. Cell. Biol. 17:7407-7416(1997).
- 2: Lu X.,J. Biol. Chem. 272:24751-24754(1997).
- 3: The MGC Project Team;Genome Res. 14:2121-2127(2004).
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
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