LTbetaR Antibody [3C8]
CATALOG NUMBER: 36-153- Clonality: Monoclonal
- Tested Applications: Functional Assays
- Host Species: Rat
- Species Reactivity: Mouse
- Conjugate: Unconjugated
- Size: 100 ug
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- HOST SPECIES: Rat
- SPECIES REACTIVITY: Mouse
- IMMUNOGEN: Recombinant mouse LTbetaR (cysteine-rich region/aa 31-221).
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: Functional Assays
- APPLICATION NOTE: Functional Application: Agonist inducing BAFF, chemokines and integrins in vitro and in vivo.
- SPECIFICITY: Recognizes mouse LTbetaR.
Properties
- PURIFICATION: >95% (SDS-PAGE)
- CLONALITY: Monoclonal
- ISOTYPE: IgG1, kappa
- PHYSICAL STATE: Liquid
- BUFFER: Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
- CONCENTRATION: 1 mg/ml
- STORAGE CONDITIONS: Stable for at least 1 year after receipt when stored at -20°C.
Additional Info
- NCBI OFFICIAL SYMBOL: Ltbr
- ADDITIONAL NAMES: Lymphotoxin-beta Receptor; Tumor Necrosis Factor Receptor 2 Related Protein; Tumor Necrosis Factor C Receptor; Tumor Necrosis Factor Receptor Superfamily Member 3; TNFRSF3
- Protein Accession Number: 1729988
- PROTEIN GI NUMBER: P50284
- NCBI GENE ID NUMBER: 17000
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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$35 Dry Ice Shipment fee may be required on some items.
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