LRRC32 Recombinant Protein
CATALOG NUMBER: 96-921- Tested Applications: ELISA, WB
- Size: 0.1 mg
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- SPECIES: Human
- SOURCE SPECIES: HEK293 cells
- RECOMBINANT PROTEIN SEQUENCE: His 20 - Asn 627
- FUSION TAG: Fc Tag
- TESTED APPLICATIONS: ELISA, WB
- APPLICATION NOTE: This recombinant protein can be used for E, WB. For research use only.
- PREDICTED MOLECULAR WEIGHT: 92.6 kDa
- BIOLOGICAL ACTIVITY: Measured by its binding ability in a functional ELISA. Immobilized Latent TGFB1, N-His at 5 ug/mL (100 uL/well) can bind Human LRRC32, Fc Tag with a linear range of 0.039-2.5 ug/mL.
Properties
- PURITY: >95% as determined by SDS-PAGE.
Endotoxin level is less than 1.0 EU per ug by the LAL method. - PHYSICAL STATE: Lyophilized
- BUFFER: Tris with Glycine, Arginine and NaCl, pH7.5
- STORAGE CONDITIONS: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Additional Info
- NCBI OFFICIAL SYMBOL: LRRC32
- ADDITIONAL NAMES: GARP,Garpin,D11S833E
- Protein Accession Number: Q14392-1
- NCBI GENE ID NUMBER: 2615
Background
- Leucine-rich repeat protein 32 (LRRC32), also known as GARP (glycoprotein A repetitions predominant). LRRC32 expression promotes the acquisition of a Treg phenotype including reduced cellular proliferation, reduced cytokine secretion, and the capacity to suppress the proliferation of naïve T cells. LRRC32 binds directly to the TGF-beta latency associated peptide (LAP) and tethers latent TGF-beta on the surface of activated Treg cells. The presentation of TGF-beta on Tregs contributes to their ability to suppress naïve T cell proliferation.
- 1: Battaglia, M., et al., 2009, Eur. J. Immunol. 39(12): 3296-3300.
- 2: Wang, R. et al. 2008, PloS ONE 3(7): e2705.
- 3: Probst-Kepper, M. et al. 2009, J. Cell. Mol. Med. 13(9B): 3343-3357.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
Shipping Info
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