• Skip to main content
  • Skip to footer
Close Hamburger Menu Close Hamburger Menu
  • New / Featured Products
  • Advanced Validation
  • Support
  • Promotions
  • Loyalty Program
  • Blog
  • About Us
  • ProSci Distributors

ProSci Incorporated

  • (888) 513-9525
  • Search Icon Open Search Box
  • Sign In
  • Cart Icon
  • Open Hamburger Menu Open Hamburger Menu
  • COVID-19
  • Products
    • Primary Antibodies
    • Secondary Antibodies
    • More
      • Antibody Pairs
      • Biosimilars
      • Chemical
      • Control Antibodies
      • Detection Sets
      • Functional Antibodies
      • Immunoblots
      • Lysates
      • Peptides
      • Pseudoviruses
      • Recombinant Proteins
      • Slides
  • Custom Services
  • Applications & Techniques
  • Contact
  • New / Featured Products
  • Advanced Validation
  • Support
  • Promotions
  • Loyalty Program
  • Blog
  • About Us
  • ProSci Distributors
Home / Human / LKB1 (phospho Ser428) Antibody
LKB1 (phospho Ser428) Antibody
LKB1 (phospho Ser428) Antibody

LKB1 (phospho Ser428) Antibody

CATALOG NUMBER: 80-029
  • Clonality: Polyclonal
  • Tested Applications: WB
  • Host Species: Rabbit
  • Species Reactivity: Human, Mouse
  • Conjugate: Unconjugated
  • Size: 0.1 mg
Powered by Bioz

Specifications

  • HOST SPECIES: Rabbit
  • SPECIES REACTIVITY: Human, Mouse
  • IMMUNOGEN: LKB1 (phospho Ser428) antibody was raised against a peptide sequence around phosphorylation site of serine428 (R-L-S (p)-A-C) derived from Human LKB1 .
  • CONJUGATE: Unconjugated
  • TESTED APPLICATIONS: WB
  • APPLICATION NOTE: Western Blot: 1:500~1:1000
  • SPECIFICITY: The antibody detects endogenous level of LKB1 only when phosphorylated at serine 428.
  • PREDICTED MOLECULAR WEIGHT: 65 kDa

Properties

  • PURIFICATION: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • CLONALITY: Polyclonal
  • ISOTYPE: IgG
  • PHYSICAL STATE: Liquid
  • BUFFER: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • CONCENTRATION: 1 mg/mL
  • STORAGE CONDITIONS: Store antibody at -20°C for up to one year.

Additional Info

  • NCBI OFFICIAL SYMBOL: STK11
  • ADDITIONAL NAMES: Protein kinase, CAMK group, CAMKL family, LKB subfamily,
  • Protein Accession Number: NP_000446.1
  • PROTEIN GI NUMBER: 17939640
  • NCBI GENE ID NUMBER: 6794

Background

  • Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2: it thereby regulates inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neurons polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1 Also acts as a mediator p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways.
  • 1: Zhu H, et al. (2013) J Biol Chem 288, 16495-505. Seto SW, et al. (2013) PLoS One 8, e66404 . Rosario FJ, et al. (2012)J Physiol 590, 1495-509.

Disclaimer

  • FOR RESEARCH USE ONLY
    For additional information, visit ProSci's Terms & Conditions Page.
  • Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Powered by Bioz See more details on Bioz

CATALOG NUMBER: 80-029

  • Size: 0.1 mg
  • List Price: $335.00
Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

Note: Online orders only accepted for shipment within the USA. Click here for the list of international distributors.

Customize your order

Bulk Pricing Available

Custom Formulations: azide free, endotoxin testing & endotoxin removal.

Pair your antibody with a Lysate, Peptide, Control, & /OR Secondary Antibody.

Contact our Customer Care Team for more information

Custom Antibody Services 

Speak to one of our custom antibody specialists to discuss your next custom antibody project.

New & Featured Products
HIV-1 p24 Antibody [10A2] (biotin)
HIV-1 p24 Antibody [10A2] (biotin)

CATALOG NUMBER: PM-7371-biotin

HIV-1 p24 Antibody [9D2F6] (biotin)
HIV-1 p24 Antibody [9D2F6] (biotin)

CATALOG NUMBER: PM-7369-biotin

HIV-1 p24 Antibody [8D7E11] (biotin)
HIV-1 p24 Antibody [8D7E11] (biotin)

CATALOG NUMBER: PM-7367-biotin

Menu

  • Primary Antibodies
  • Secondary Antibodies
  • Recombinant Proteins
  • Applications & Techniques
  • Support
  • Loyalty Program
  • Blog
  • Promotions
  • About Us
  • ProSci Distributors
Custom Antibody Services

Contact

12170 Flint Place
Poway, CA 92064, USA

Phone:   +1 (888) 513-9525
Local:    +1 (858) 513-2638
Fax:       +1 (858) 513-2692

customercare@prosci-inc.com
techsupport@prosci-inc.com

Follow

  • Facebook
  • Twitter
  • LinkedIn
  • Pinterest
  • Instagram
Copyright © 2023 ProSci Incorporated | All Rights Reserved | Terms & Conditions | Privacy Policy | Accessibility Feedback | Design by TinyFrog Technologies
We use cookies on our website to give you the most relevant experience by remembering your preferences and repeat visits. By clicking “Accept”, you consent to the use of cookies.
Accept Reject
Manage consent

Privacy Overview

This website uses cookies to improve your experience while you navigate through the website. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience.
Necessary
Always Enabled
Necessary cookies are absolutely essential for the website to function properly. These cookies ensure basic functionalities and security features of the website, anonymously.
CookieDurationDescription
cookielawinfo-checbox-analytics11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Analytics".
cookielawinfo-checbox-functional11 monthsThe cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional".
cookielawinfo-checbox-others11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other.
cookielawinfo-checkbox-necessary11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary".
cookielawinfo-checkbox-performance11 monthsThis cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance".
viewed_cookie_policy11 monthsThe cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.
Functional
Functional cookies help to perform certain functionalities like sharing the content of the website on social media platforms, collect feedbacks, and other third-party features.
Performance
Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors.
Analytics
Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc.
Advertisement
Advertisement cookies are used to provide visitors with relevant ads and marketing campaigns. These cookies track visitors across websites and collect information to provide customized ads.
Others
Other uncategorized cookies are those that are being analyzed and have not been classified into a category as yet.
SAVE & ACCEPT