Lipoma Preferred Partner Antibody
CATALOG NUMBER: 36-343- Clonality: Polyclonal
- Tested Applications: ICC, IP, WB
- Host Species: Rabbit
- Species Reactivity: Human, Pig, Rat
- Conjugate: Unconjugated
- Size: 50 ug
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Pig, Rat
- IMMUNOGEN: Recombinant human lipoma preferred partner (LPP) (aa 1-109).
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: ICC, IP, WB
- APPLICATION NOTE: Immunocytochemistry: (1:500). Immunohistochemistry: (1:500). Western Blot: (1:1,000) . Optimal conditions must be determined individually for each application.
- SPECIFICITY: Recognizes human, rat and pig LPP.
Properties
- PURIFICATION: Antigen affinity purified.
- CLONALITY: Polyclonal
- PHYSICAL STATE: Liquid
- BUFFER: Liquid. In PBS containing 0.01% sodium azide.
- CONCENTRATION: 500 ug/ml
- STORAGE CONDITIONS: Stable for at least 1 year after receipt when stored at -20°C.
Additional Info
- NCBI OFFICIAL SYMBOL: LPP
- ADDITIONAL NAMES: LPP; LIM Domain-containing Preferred Translocation Partner in Lipoma
- Protein Accession Number: 264681524
- PROTEIN GI NUMBER: NP_001161143.1
- NCBI GENE ID NUMBER: 4026
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- Lipoma preferred partner (LPP) is encoded by the preferred fusion partner gene of the high mobility group protein HMGI-C. LPP is frequently affected by chromosomal translocations in a major group of soft tissue lipomas, as well as in a parosteal lipoma and in pulmonary chondroid hamartomas. The resulting fusion proteins comprise three DNA binding domains of HMGI-C fused to two or three C-terminal LIM domains of LPP and a reciprocal product, respectively. Expression of a HMGI-C/LPP fusion protein causes malignant transformation of fibroblasts. Similar to its relatives zyxin and TRIP (thyroid receptor interacting protein 6) / ZRP-1 (zyxin-related protein 1), LPP consists of a N-terminal proline-rich domain followed by three C-terminal LIM domains (double zinc finger structures that are involved in protein-protein interactions). Like the cytoskeletal protein zyxin, LPP localizes to focal adhesions and cell-cell adherens junctions. LPP harbors a nuclear export signal and displays transcriptional activation capacity.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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