LDLR Antibody
CATALOG NUMBER: XW-7339- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Chicken
- Species Reactivity: Human, Mouse, Rat
- Conjugate: Unconjugated
- Size: 0.05 mg
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- HOST SPECIES: Chicken
- SPECIES REACTIVITY: Human, Mouse, Rat
- IMMUNOGEN: 29-205
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: LDL-R antibody can be used for the detection of LDL-R by Western blot, may also work for IHC and ICC.
- PREDICTED MOLECULAR WEIGHT: 95.4 kDa (calculated)
Properties
- PURIFICATION: Antigen affinity-purified
- CLONALITY: Polyclonal
- PHYSICAL STATE: Liquid
- BUFFER: Phosphate-Buffered Saline. No preservatives added.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: LDLR antibody can be stored at 4°C for short term (weeks). Long term storage should be at -20°C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: LDLR
- ADDITIONAL NAMES: Low-density lipoprotein receptorLDL receptor, FH, FHC, LDLCQ2, LDLR
- Protein Accession Number: NP_000518.1
- PROTEIN GI NUMBER: 4504975
- NCBI GENE ID NUMBER: 3949
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- Low density lipoprotein receptor. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia.
- 1: Agnello, V., Abel, G., Elfahal, M., Knight, G. B., Zhang, Q. -X. Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor. Proc. Nat. Acad. Sci. 96: 12766-12771, 1999.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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