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KPNA5 Antibody
CATALOG NUMBER: 5989- Clonality: Polyclonal
- Tested Applications: ELISA, IHC-P
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 0.02 mg | 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Rat: (81%)
- IMMUNOGEN: KPNA5 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human KPNA5.
The immunogen is located within amino acids 30 - 80 of KPNA5. - CONJUGATE: Unconjugated
- TESTED APPLICATIONS: ELISA, IHC-P
- APPLICATION NOTE: KPNA5 antibody can be used for detection of KPNA5 by immunohistochemistry at 5 μg/mL.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested. - SPECIFICITY: KPNA5 antibody is human specific. KPNA5 antibody is predicted to not cross-react with other Importin alpha family members.
- POSITIVE CONTROL 1: Cat. No. 11-701 - Human Testis Tissue Slide
Properties
- PURIFICATION: KPNA5 Antibody is affinity chromatography purified via peptide column.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: KPNA5 Antibody is supplied in PBS containing 0.02% sodium azide.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: KPNA5 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: KPNA5
- ADDITIONAL NAMES: KPNA5 Antibody: SRP6, IPOA6, Importin subunit alpha-6, Karyopherin subunit alpha-5
- Protein Accession Number: CAH71948
- PROTEIN GI NUMBER: 55664992
- NCBI GENE ID NUMBER: 3841
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- KPNA5 Antibody: Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA5 belongs to a subfamily within the KPNA family that also includes KPNA4 and 6 and is thought to be involved in NLS-dependent protein import into the nucleus.
- 1: Moroianu J. Molecular mechanisms of nuclear protein transport. Crit. Rev. Eukaryot. Gene. Expr. 1997; 7:61-72.
- 2: Gilchrist D and Rexach M. Molecular basis for the rapid dissociation of nuclear localization signals from karyopherin alpha in the nucleoplasm. J. Biol. Chem. 2003; 278: 51937-49.
- 3: Kohler MC, Fiebeler M, Hartwig S, et al. Evidence for distinct substrate specificity of importin alpha family members in nuclear protein import. Mol. Cell. Biol. 1999; 19:7782-91.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
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