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IRAK Antibody [8F1A7]IRAK Antibody [8F1A7]
IRAK Antibody [8F1A7]
IRAK Antibody [8F1A7]
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IRAK Antibody [8F1A7]

CATALOG NUMBER: PM-5317
  • Clonality: Monoclonal
  • Tested Applications: E, IHC-P, WB
  • Host Species: Mouse
  • Species Reactivity: Human, Mouse
  • Conjugate: Unconjugated
  • Size: 0.02 mg | 0.1 mg

Specifications

  • HOST SPECIES: Mouse
  • SPECIES REACTIVITY: Human, Mouse
  • IMMUNOGEN: Recombinant protein corresponding to amino acids 618 - 712 of human IRAK.
  • CONJUGATE: Unconjugated
  • TESTED APPLICATIONS: E, IHC-P, WB
  • APPLICATION NOTE: IRAK antibody can be used for Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
    Antibody validated: Western Blot in mouse samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.
  • POSITIVE CONTROL 1: Cat. No. 95-112 - IRAK Recombinant Protein

Properties

  • PURIFICATION: IRAK Monoclonal Antibody is Protein G purified.
  • CLONALITY: Monoclonal
  • ISOTYPE: IgG1
  • PHYSICAL STATE: Liquid
  • BUFFER: IRAK Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
  • CONCENTRATION: 1 mg/mL
  • STORAGE CONDITIONS: IRAK monoclonal antibody can be stored at -20°C, stable for one year.

Additional Info

  • NCBI OFFICIAL SYMBOL: IRAK1
  • ADDITIONAL NAMES: IRAK Antibody [8F1A7] : IRAK, pelle
  • Protein Accession Number: P51617
  • PROTEIN GI NUMBER: 8928535
  • NCBI GENE ID NUMBER: 3654
  • USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background

  • IRAK Monoclonal Antibody: Nuclear factor kappa B (NF-kappaB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha and LPS. A serine/threonine protein kinase associated with IL-1 receptor (IRAK) and its homologue mouse pelle-like protein kinase (mPLK) were identified recently. IRAK is associated with the IL-1 receptor subunits IL-1RI and IL-1RAcP after IL-1 binding and serves as a signaling molecule to mediate IL-1 response. IRAK mediates a signaling cascade leading to NF-κB activation by members in IL-1 family including IL-1 and a novel cytokine IL-18 (also termed IGIF).
  • 1: Cao Z,; Henzel WJ, and Gao X. IRAK: a kinase associated with the interleukin-1 receptor. Science 1996; 271:1128-31.
  • 2: Trofimova M, Sprenkle AB, Green M; et al. Developmental and tissue-specific expression of mouse pelle-like protein kinase. J. Bio. Chem. 1996; 271: 17609-12.
  • 3: Jianing Huang, Xiong Gao, Shyun Li, et al. Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin-1 receptor accessory protein. Proc. Natl. Acad. Sci. USA 1997; 94:12829-32.
  • 4: Robinson D, Shibuya K, Mui A, et al. IGIF does not drive Th1 development but synergizes with IL-12 for interferon-gamma production and activates IRAK and NF-kB. Immunity 1997; 7:571-81.

Disclaimer

  • FOR RESEARCH USE ONLY
    For additional information, visit ProSci's Terms & Conditions Page.
  • Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER: PM-5317

  • Size: 0.02 mg | 0.1 mg
  • List Price: $89.00 – $459.00
Datasheet
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