Interleukin 4 Recombinant Protein (HEK293 Expressed)
CATALOG NUMBER: 96-443- Tested Applications: WB
- Size: 0.02 mg
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- SPECIES: Human
- SOURCE SPECIES: HEK293 cells
- RECOMBINANT PROTEIN SEQUENCE: His 25 - Ser 153
- FUSION TAG: Tag free
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: This recombinant protein can be used for WB. For research use only.
- PREDICTED MOLECULAR WEIGHT: 14.9 kDa
- BIOLOGICAL ACTIVITY: The bio-activity was determined by dose-dependent stimulation of the proliferation of TF-1 cells. The ED50 < 0. 2 ng/mL, corresponding to a specific activity of >5X106 Unit/mg.
Properties
- PURITY: >90% as determined by SDS-PAGE.
- PHYSICAL STATE: Lyophilized
- BUFFER: 20 mM Na2HPO4, 200 mM NaCl, pH7.0
- STORAGE CONDITIONS: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Additional Info
- NCBI OFFICIAL SYMBOL: IL4
- ADDITIONAL NAMES: IL4, BCGF1, BSF1
- Protein Accession Number: AAH67514
- NCBI GENE ID NUMBER: 3565
Background
- Interleukin-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells). In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Recently, researcher found that the cytokine IL-4 plays a key role in development of innate CD8+ T cells in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3, without previous exposure to antigen.
- 1: Callard RE., et al., 1991, Br J Haematol. Jul;78(3):293-9.
- 2: Varin A, Gordon S., et al., 2009, Immunobiology. 214(7):630-41.
- 3: Finkelman FD, et al., 2004, Immunol Rev. 201:139-55.
- 4: Lee YJ, Jameson SC,et al., 2011, Trends Immunol. 32(2):50-6. Epub 2011 Feb 1.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
Shipping Info
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