Interferon-a Receptor (phospho Ser535 / 539) Antibody
CATALOG NUMBER: XPS-1014- Clonality: Polyclonal
- Tested Applications: IHC, WB
- Host Species: Rabbit
- Species Reactivity: Bovine, Human, Mouse, Rat
- Conjugate: Unconjugated
- Size: 0.1 mL
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Bovine, Human, Mouse, Rat
- IMMUNOGEN: IFNAR1 (Ser535/539) polyclonal antibody was raised against a synthetic phosphopeptide corresponding to amino acid residues surrounding the human Phospho-Ser535, 539 Type I Interferon-a Receptor Subunit 1 (IFNAR1).
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: IHC, WB
- APPLICATION NOTE: Applications include Dot Blots (DB) and Western Blots (WB). Suitability for Immunohistochemistry (IHC) has not yet been determined. When internally tested under ideal conditions the working dilutions were 1:1000 for DB and WB.
- SPECIFICITY: Interferon a Receptor antibody is specific for IFNAR1 phosphorylated at Ser535,539.
- PREDICTED MOLECULAR WEIGHT: 110-130
Properties
- PURIFICATION: Affinity Purified
- CLONALITY: Polyclonal
- PHYSICAL STATE: Liquid
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: For long term storage –80°C is recommended, but shorter term storage at –20°C is also acceptable as aliquots may be taken without freeze/thawing due to the presence of 50% glycerol. Stable for one year.
Additional Info
- NCBI OFFICIAL SYMBOL: IFNAR1
- Protein Accession Number: P17181
- PROTEIN GI NUMBER: 90110827
- NCBI GENE ID NUMBER: 3454
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- Interferons are widely used therapeutic agents because of their anti tumor and antiviral effects and because of their modulatory effects on the immune system. These cytokines produce their effects by binding to the Type 1 Interferon-alpha Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1.
- 1: Suresh Kumar, K.G., Tang, W., Ravindranath, A.K., Clark, W.A., Croze, E., Fuchs, S.Y., "SCFHOS ubiquitin ligase mediates the ligand-induced down-regulation of the interferon- receptor," The EMBO Journal, 22 (2003), 5480-5490.
- 2: Kirkwood, J., "Cancer immunotherapy: the interferon- experience," Semin. Oncol., 29 (2002) 18-26.
- 3: Biron, C.A., "Interferons alpha and beta as immune regulators-a new look," Immunity, 14 (2001) 661-664.
- 4: Stark, G.R., Kerr, I.M., Williams, B.R., Silverman, R.H. and Schreiber, R.D. "How cells respond to interferons." Annu. Rev. Biochem., 67 (1998) 227-264.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: This product is for research use only.
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