INHBA Antibody
CATALOG NUMBER: 55-651- Clonality: Polyclonal
- Tested Applications: Flow, IF, IHC-P, WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
- IMMUNOGEN: This INHBA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-112 amino acids from the N-terminal region of human INHBA.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: Flow, IF, IHC-P, WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For IF starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50 - PREDICTED MOLECULAR WEIGHT: 47 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: INHBA
- ADDITIONAL NAMES: Inhibin beta A chain, Activin beta-A chain, Erythroid differentiation protein, EDF, INHBA
- Protein Accession Number: P08476
- PROTEIN GI NUMBER: 124279
- NCBI GENE ID NUMBER: 3624
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- The inhibin beta A subunit joins the alpha subunit to forma pituitary FSH secretion inhibitor. Inhibin has been shown toregulate gonadal stromal cell proliferation negatively and to havetumor-suppressor activity. In addition, serum levels of inhibinhave been shown to reflect the size of granulosa-cell tumors andcan therefore be used as a marker for primary as well as recurrentdisease. Because expression in gonadal and various extragonadaltissues may vary severalfold in a tissue-specific fashion, it isproposed that inhibin may be both a growth/differentiation factorand a hormone. Furthermore, the beta A subunit forms a homodimer,activin A, and also joins with a beta B subunit to form aheterodimer, activin AB, both of which stimulate FSH secretion.Finally, it has been shown that the beta A subunit mRNA isidentical to the erythroid differentiation factor subunit mRNA andthat only one gene for this mRNA exists in the human genome.
- 1: Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)
- 2: Shi, F.T., et al. J. Clin. Endocrinol. Metab. 95 (10), E172-E180 (2010) :
- 3: Lascorz, J., et al. Carcinogenesis 31(9):1612-1619(2010)
- 4: Jugessur, A., et al. PLoS ONE(7), E11493 (2010) :
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
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