- SPECIES: Human
- SOURCE SPECIES: E. coli
- RECOMBINANT PROTEIN SEQUENCE: Human IL-4 (aa 25-153) is fused at the C-terminus to a His-tag.
- FUSION TAG: His Tag
- APPLICATION NOTE: This recombinant proteins is for research use only.
- PURITY: >98% (SDS-PAGE).
Endotoxin level is less than 0.1EU/ μg protein (LAL test; Lonza).
- PHYSICAL STATE: Lyophilized
- BUFFER: Lyophilized from 0.2um-filtered solution in PBS (pH 7.4). Reconstituted in sterile H2O not less than 100 μg/ml, which can then be further diluted in other aqueous solutions.
- STORAGE CONDITIONS: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
- NCBI OFFICIAL SYMBOL: IL4
- ADDITIONAL NAMES: Interleukin-4, B Cell Stimulatory Factor 1, BSF-1
- Protein Accession Number: NP_000580
- PROTEIN GI NUMBER: 4504669
- NCBI GENE ID NUMBER: 3565
- Interleukin-4 (IL-4) is a cytokine produced by type 2 helper T cells, the Th2 cells. These cells tends to make a specific set of lymphokines including IL-4, IL-5, IL-6, IL-10, IL-13, IL-3 and GM-CSF and fail to produce IL-2, IFN-gamma, and lymphotoxin (TNF-beta). In addition, mast cells can produce IL-4. IL-4 exerts numerous effects on various hematopoietic cell types. On B cells, IL-4 promotes immunoglobulin class switching to IgE and IgG1 isotypes and upregulates MHC class II and CD23 expression. IL-4 promotes survival, growth, and differentiation of both T and B lymphocytes, mast cells and endothelial cells. In addition, IL-4 inhibits the production of TNF, IL-1, and IL-6 by macrophages.
- FOR RESEARCH USE ONLY
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- Disclaimer: Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
CATALOG NUMBER: 90-476
- Size: 10 ug
- List Price: $295.00
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