- SPECIES: Cynomolgus, Rhesus macaque
- SOURCE SPECIES: HEK293 cells
- RECOMBINANT PROTEIN SEQUENCE: Met 26 - Arg 232
- FUSION TAG: Fc Tag
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: This recombinant protein can be used for WB. For research use only.
- PREDICTED MOLECULAR WEIGHT: 50.4 kDa
- PURITY: >95% as determined by SDS-PAGE.
Endotoxin level is less than 1.0 EU per ug by the LAL method.
- PHYSICAL STATE: Lyophilized
- BUFFER: Tris with Glycine, Arginine and NaCl, pH7.5
- STORAGE CONDITIONS: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
- NCBI OFFICIAL SYMBOL: IL-4 R alpha
- ADDITIONAL NAMES: IL4R,CD124,IL4RA
- Protein Accession Number: G7Q0S7
- IL-4 is a pleiotropic cytokine produced by activated Th2 cells and mast cells, and plays a pivotal role in immune responses. The effects of IL-4 are mediated after binding to high affinity receptor complexes present on hematopoietic as well as non-hematopoietic cells. Hematopoietic cellular responses to IL-4 are mediated by a high affinity receptor complex comprised of the 140 kDa IL4Ralpha (CD124)subunit and the 70 kDa common cytokine γc chain (CD132).Interleukin 4 Receptor (IL4R) also known as CD124, IL4Ralpha and BSF receptor, is a type I cytokine receptor produced by activated Th2 cells and mast cells, and plays an important role in Th2-biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. A soluble form of the encoded IL4R protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. IL4R can alternatively associate with IL13Ra1 to form the type II receptor which is responsive to both IL4 and IL13. Interleukin-4 receptor has been shown to interact with SHC1.
- 1: Ikizawa, K., et al., 2000, Biochem. Biophys. Res. Commun. (UNITED STATES) 268 : 54–9.
- 2: Kashiwada, M., et al., 2001, J. Immunol. (United States) 167 (11): 6382–7.
- 3: Hage T., et al., 1999, Cell 97 (2): 271–81.
- 4: Gessner,A. et al., 2000, Immunobiology. 201 (3-4): 285-307.
- FOR RESEARCH USE ONLY
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CATALOG NUMBER: 96-797
- Size: 0.05 mg
- List Price: $430.00
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