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IL-23 AntibodyIL-23 AntibodyIL-23 AntibodyIL-23 AntibodyIL-23 AntibodyIL-23 AntibodyIL-23 AntibodyIL-23 Antibody
IL-23 Antibody
IL-23 Antibody
IL-23 Antibody
IL-23 Antibody
IL-23 Antibody
IL-23 Antibody
IL-23 Antibody
IL-23 Antibody
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IL-23 Antibody

CATALOG NUMBER: 3793
  • Clonality: Polyclonal
  • Tested Applications: ELISA, ICC, IF, IHC-P, WB
  • Host Species: Rabbit
  • Species Reactivity: Human
  • Conjugate: Unconjugated
  • Size: 0.02 mg | 0.1 mg

Specifications

  • HOST SPECIES: Rabbit
  • SPECIES REACTIVITY: Human
  • HOMOLOGY: Predicted species reactivity based on immunogen sequence: Guinea pig: (93%), Horse: (93%), Mouse: (71%), Rat: (71%)
  • IMMUNOGEN: Anti-IL-23 antibody (3793) was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of mature human IL-23.
    The immunogen is located the last 50 amino acids of IL-23.
  • CONJUGATE: Unconjugated
  • TESTED APPLICATIONS: ELISA, ICC, IF, IHC-P, WB
  • APPLICATION NOTE: WB: 1-4 μg/mL; ICC: 10 μg/mL; IF: 20 μg/mL, IHC: 5 μg/mL.
    Antibody validated: Western Blot, Immunocytochemistry, Immunofluorescence and Immunohistochemistry in human samples. All other applications and species not yet tested.
  • POSITIVE CONTROL 1: Cat. No. 1207 - Raji Cell Lysate
  • POSITIVE CONTROL 2: Cat. No. 11-101 - Human Pancreas Tissue Slide
  • POSITIVE CONTROL 3: Cat. No. 17-007 - Raji Cell Slide
  • PREDICTED MOLECULAR WEIGHT: Predicted: 21kD
    Observed: 22 kD

Advanced Validation

  • VALIDATION:

    Recombinant Protein Test (Figure 3): Anit-IL-23 antibodies (3793) detected human IL-23 recombinant protein.

     

    Regulated expression validation (Figure 8): IL-23 expression detected by anit-IL-23 antibodies (3793) was abundant in human abdominal aortic aneurysm (AAA) tissues whereas there is no IL-23 expression in normal tissue.

  • ISOFORMS: Human IL-23 has one isoform (189aa, 20.7kD). Mouse IL-23 has one isoform (196aa, 22.1kD) and Rat IL-23 also has one isoform (196aa, 22kD). 3793 can detect human IL-23.

Properties

  • PURIFICATION: IL-23 Antibody is affinity chromatography purified via peptide column.
  • CLONALITY: Polyclonal
  • ISOTYPE: IgG
  • PHYSICAL STATE: Liquid
  • BUFFER: IL-23 Antibody is supplied in PBS containing 0.02% sodium azide.
  • CONCENTRATION: 1 mg/mL
  • STORAGE CONDITIONS: IL-23 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Additional Info

  • NCBI OFFICIAL SYMBOL: IL23A
  • ADDITIONAL NAMES: IL-23 Antibody: P19, SGRF, IL-23, IL-23A, IL23P19, UNQ2498/PRO5798, Interleukin-23 subunit alpha, Interleukin-23 subunit p19, IL-23 subunit alpha
  • Protein Accession Number: AAH66268
  • PROTEIN GI NUMBER: 42542809
  • NCBI GENE ID NUMBER: 51561
  • USER NOTE: Optimal dilutions for each application to be determined by the researcher.

Background

  • IL-23 Antibody: Like interleukin-27 (IL-27), IL-23 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the IL-12p40 subunit and a novel p19 subunit. IL-23 is secreted by activated dendritic cells, macrophages, and monocytes. Its biological activities include enhancing the proliferation of memory T cells and the production of IFN-gamma, IL-12, and TNF-α from activated T cells, and can stimulate macrophages to produce TNF-α and nitric oxide. It has also been shown to possess potent anti-tumor and anti-metastatic activity in mouse models of cancer, suggesting a potential role for IL-23 in therapeutic treatment of cancer.
  • 1: Hunter. Nat. Rev. Immunol. 2005; 5:521-31.
  • 2: Oppmann et al. Immunity 2000; 13:715-25.
  • 3: Sheibanie et al. FASEB J. 2004; 18:1318-20.
  • 4: Pirhonen et al. J. Immunol. 2002; 169:5673-8.

Citations

  • 1: Yan et al. Interleukin-12 and -23 blockade mitigates elastase-induced abdominal aortic aneurysm. Sci Rep. 2019;9(1):10447.PMID: 31320700

Disclaimer

  • FOR RESEARCH USE ONLY
    For additional information, visit ProSci's Terms & Conditions Page.
  • Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER: 3793

  • Size: 0.02 mg | 0.1 mg
  • List Price: $89.00 – $395.00
Datasheet
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