IKK-γ (phospho Ser376) Antibody
CATALOG NUMBER: 79-846- Clonality: Polyclonal
- Tested Applications: IHC
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- IMMUNOGEN: IKK-γ (phospho Ser376) antibody was raised against a peptide sequence around phosphorylation site of Serine 376 (Y-L-S (p)-S-P) derived from Human IKK-γ.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: IHC
- SPECIFICITY: The antibody detects endogenous levels of IKK-γ only when phosphorylated at serine 376.
- PREDICTED MOLECULAR WEIGHT: 48 kDa
Properties
- PURIFICATION: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: Store antibody at -20°C for up to one year.
Additional Info
- NCBI OFFICIAL SYMBOL: IKBKG
- ADDITIONAL NAMES: FIP3, IKBKG, IKKAP1, IKKG, NF-kappaB
- Protein Accession Number: NP_001093327.1
- PROTEIN GI NUMBER: 3641279
- NCBI GENE ID NUMBER: 8517
Background
- Familial incontinentia pigmenti (IP) is a genodermatosis that segregates as an X-linked dominant disorder and is usually lethal prenatally in males. In affected females it causes highly variable abnormalities of the skin, hair, nails, teeth, eyes, and central nervous system. The prominent skin signs occur in 4 classic cutaneous stages: perinatal inflammatory vesicles, verrucous patches, a distinctive pattern of hyperpigmentation, and dermal scarring. Cells expressing the mutated X chromosome are eliminated selectively around the time of birth, so females with IP exhibit extremely skewed X-inactivation.
- 1: Li Y., Proc. Natl. Acad. Sci. U.S.A. 96:1042-1047(1999).
- 2: Jin D.-Y., J. Biomed. Sci. 6:115-120(1999).
- 3: Rothwarf D.M., Nature 395:297-300(1998).
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
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