- SPECIES: Human cytomegalovirus
- SOURCE SPECIES: HEK293 cells
- RECOMBINANT PROTEIN SEQUENCE: His 67 - Arg 297
- FUSION TAG: His Tag
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: This recombinant protein can be used for WB. For research use only.
- PREDICTED MOLECULAR WEIGHT: 26.2 kDa
- PURITY: >90% as determined by SDS-PAGE.
Endotoxin level is less than 1.0 EU per ug by the LAL method.
- PHYSICAL STATE: Lyophilized
- BUFFER: PBS, pH7.4
- STORAGE CONDITIONS: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
- NCBI OFFICIAL SYMBOL: Glycoprotein / GP (virus)
- ADDITIONAL NAMES: HRSV Glycoprotein G
- Protein Accession Number: P20895
- NCBI GENE ID NUMBER: 144411
- Human respiratory syncytial virus (HRSV) is the most common etiological agent of acute lower respiratory tract disease in infants and can cause repeated infections throughout life. Human respiratory syncytial virus A (strain Long) major surface glycoprotein G (RSV-G), a member of the pneumoviruses glycoprotein G family, is also known as attachment glycoprotein G and membrane-bound glycoprotein (mG), which contains a linear heparin binding domain essential for virus attachment to the host. Concretely speaking, RSV-G can attache the virion to the host cell membrane by interacting with heparan sulfate, initiating the infection. Furthermore, RSV-G can also interact with host CX3CR1, the receptor for the CX3C chemokine fractalkine, to modulate the immune response and facilitate infection. Unlike the other paramyxovirus attachment proteins, RSV-G lacks both neuraminidase and hemagglutinating activities.
- 1: Hendricks D.A., et al., 1986, J. Gen. Virol. 68:1705-1714.
- 2: Bao X., et al., 2008, PLoS Pathog. 4 (5): e1000077.
- FOR RESEARCH USE ONLY
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CATALOG NUMBER: 97-054
- Size: 0.05 mg
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