HIRA Antibody
CATALOG NUMBER: 58-871- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Mouse
- IMMUNOGEN: This HIRA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-61 amino acids from the N-terminal region of human HIRA.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
- PREDICTED MOLECULAR WEIGHT: 112 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: HIRA
- ADDITIONAL NAMES: Protein HIRA, TUP1-like enhancer of split protein 1, HIRA, DGCR1, HIR, TUPLE1
- Protein Accession Number: P54198
- PROTEIN GI NUMBER: 88984228
- NCBI GENE ID NUMBER: 7290
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- This gene encodes a histone chaperone that preferentiallyplaces the variant histone H3.3 in nucleosomes. Orthologs of thisgene in yeast, flies, and plants are necessary for the formation oftranscriptionally silent heterochomatin. This gene plays animportant role in the formation of the senescence-associatedheterochromatin foci. These foci likely mediate the irreversiblecell cycle changes that occur in senescent cells. It is consideredthe primary candidate gene in some haploinsufficiency syndromessuch as DiGeorge syndrome, and insufficient production of the genemay disrupt normal embryonic development.
- 1: Bailey, S.D., et al. Diabetes Care (2010) In press :
- 2: Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
- 3: Banumathy, G., et al. Mol. Cell. Biol. 29(3):758-770(2009)
- 4: Ramelli, G.P., et al. Dev Med Child Neurol 50(12):953-955(2008)
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
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