HIF1A Antibody
CATALOG NUMBER: 60-903- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Bovine
- IMMUNOGEN: This HIF1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 735-762 amino acids from the C-terminal region of human HIF1A.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
- PREDICTED MOLECULAR WEIGHT: 93 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: HIF1A
- ADDITIONAL NAMES: Hypoxia-inducible factor 1-alpha, HIF-1-alpha, HIF1-alpha, ARNT-interacting protein, Basic-helix-loop-helix-PAS protein MOP1, Class E basic helix-loop-helix protein 78, bHLHe78, Member of PAS protein 1, PAS domain-containing protein 8, HIF1A, BHLHE78, MOP1, PASD8
- Protein Accession Number: Q16665
- PROTEIN GI NUMBER: 2498017
- NCBI GENE ID NUMBER: 3091
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- Hypoxia-inducible factor-1 (HIF1) is a transcriptionfactor found in mammalian cells cultured under reduced oxygentension that plays an essential role in cellular and systemichomeostatic responses to hypoxia. HIF1 is a heterodimer composed ofan alpha subunit and a beta subunit. The beta subunit has beenidentified as the aryl hydrocarbon receptor nuclear translocator(ARNT). This gene encodes the alpha subunit of HIF-1.Overexpression of a natural antisense transcript (aHIF) of thisgene has been shown to be associated with nonpapillary renalcarcinomas. Two alternative transcripts encoding different isoformshave been identified.
- 1: Gonsalves, C., et al. J. Immunol. 185(10):6253-6264(2010)
- 2: Hindryckx, P., et al. J. Immunol. 185(10):6306-6316(2010)
- 3: Espinosa, I., et al. Am. J. Surg. Pathol. 34(11):1708-1714(2010)
- 4: Corzo, C.A., et al. J. Exp. Med. 207(11):2439-2453(2010)
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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