HERPUD1 Antibody
CATALOG NUMBER: 59-043- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- IMMUNOGEN: This HERPUD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the N-terminal region of human HERPUD1.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
- PREDICTED MOLECULAR WEIGHT: 44 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: HERPUD1
- ADDITIONAL NAMES: Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein, Methyl methanesulfonate (MMF)-inducible fragment protein 1, HERPUD1, HERP, KIAA0025, MIF1
- Protein Accession Number: Q15011
- PROTEIN GI NUMBER: 3123034
- NCBI GENE ID NUMBER: 9709
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- The accumulation of unfolded proteins in the endoplasmicreticulum (ER) triggers the ER stress response. This responseincludes the inhibition of translation to prevent furtheraccumulation of unfolded proteins, the increased expression ofproteins involved in polypeptide folding, known as the unfoldedprotein response (UPR), and the destruction of misfolded proteinsby the ER-associated protein degradation (ERAD) system. This genemay play a role in both UPR and ERAD. Its expression is induced byUPR and it has an ER stress response element in its promoter regionwhile the encoded protein has an N-terminal ubiquitin-like domainwhich may interact with the ERAD system. This protein has beenshown to interact with presenilin proteins and to increase thelevel of amyloid-beta protein following its overexpression.Alternative splicing of this gene produces multiple transcriptvariants, some encoding different isoforms. The full-length natureof all transcript variants has not been determined. [provided byRefSeq].
- 1: Hirabayashi, Y., et al. J. Immunol. 184(6):3276-3283(2010)
- 2: McLaughlin, M., et al. J. Biol. Chem. 285(10):6960-6969(2010)
- 3: Zabaneh, D., et al. PLoS ONE(8), E11961 (2010) :
- 4: Ridker, P.M., et al. Circ Cardiovasc Genet 2(1):26-33(2009)
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
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