HER2 (phospho Tyr1248) Antibody
CATALOG NUMBER: 79-140- Clonality: Polyclonal
- Tested Applications: IF, IHC, WB
- Host Species: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Conjugate: Unconjugated
- Size: 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse, Rat
- IMMUNOGEN: HER2 (Phospho-Tyr1248) antibody was raised against a peptide sequence around phosphorylation site of tyrosine1248 (P-E-Y (p) -L-G) derived from Human HER2.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: IF, IHC, WB
- APPLICATION NOTE: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
- SPECIFICITY: This antibody detects endogenous level of HER2 only when phosphorylated at tyrosine1248.
- PREDICTED MOLECULAR WEIGHT: 185 kDa
Properties
- PURIFICATION: Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
- CLONALITY: Polyclonal
- PHYSICAL STATE: Liquid
- BUFFER: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: Store antibody at -20°C for up to one year.
Additional Info
- NCBI OFFICIAL SYMBOL: ERBB2
- ADDITIONAL NAMES: NEU, NGL, HER2, TKR1, CD340, HER-2, MLN19, HER-2/neu, AMPK1, C-erbB-2, ErbB2
- Protein Accession Number: NP_001005862.1
- PROTEIN GI NUMBER: 54792098
- NCBI GENE ID NUMBER: 2064
Background
- Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-alpha and amphiregulin.
- 1: Yuan, Lu Qian, Ming Shi, et al. (2008) HER2-dependent MMP-7 expression is mediated by activated STAT3 Guogang Cellular Signalling, 20:1284–1291.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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