HDAC4 / HDAC5 / HDAC9 (Ab 246 / 259 / 220) Antibody
CATALOG NUMBER: 79-424- Clonality: Polyclonal
- Tested Applications: IF, IHC, WB
- Host Species: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Conjugate: Unconjugated
- Size: 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse, Rat
- IMMUNOGEN: HDAC4/HDAC5/HDAC9 (Ab-246/259/220) antibody was raised against a peptide sequence around aa.244~248/257~261/218~222 (T-A-S-E-P) derived from Human HDAC4/HDAC5/HDAC9.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: IF, IHC, WB
- APPLICATION NOTE: Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
- SPECIFICITY: This antibody detects endogenous level of total HDAC4/HDAC5/HDAC9 protein.
- PREDICTED MOLECULAR WEIGHT: 140, 124 kDa
Properties
- PURIFICATION: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
- CLONALITY: Polyclonal
- PHYSICAL STATE: Liquid
- BUFFER: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: Store antibody at -20°C for up to one year.
Additional Info
- NCBI OFFICIAL SYMBOL: HDAC4 HDAC5 HDAC9
- ADDITIONAL NAMES: HD4, AHO3, BDMR, HDACA, HA6116, HDAC-4, HDAC-A, RNF1, HD4/HD5/HD9
- Protein Accession Number: NP_006028.2;NP_001015053.1;NP_055522.1
- PROTEIN GI NUMBER: 153085395 / 62750349 / 7662280
- NCBI GENE ID NUMBER: 9759;10014;9734
Background
- Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D.
- 1: Cress, W. D. and Seto, E. (2000) J Cell Physiol 184, 1-16. Vigushin, D. M. and Coombes, R. C. (2004) Curr. Cancer Drug Targets 4, 205-218. Marmorstein, R. (2001) Cell Mol Life Sci 58, 693-703. Thiagalingam, S. et al. (2003) Ann. N. Y. Acad. Sci. 983, 84-100.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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