H2AFZ Antibody
CATALOG NUMBER: 55-724- Clonality: Polyclonal
- Tested Applications: IHC-P, WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Bovine, C. Elegans, Chicken, Zebrafish, Drosophila, Mouse, Rabbit, Xenopus, Rat
- IMMUNOGEN: This H2AFZ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-86 amino acids from the C-terminal region of human H2AFZ.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: IHC-P, WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50 - PREDICTED MOLECULAR WEIGHT: 14 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: H2AFZ
- ADDITIONAL NAMES: Histone H2AZ, H2A/z, H2AFZ, H2AZ
- Protein Accession Number: P0C0S5
- PROTEIN GI NUMBER: 83288408
- NCBI GENE ID NUMBER: 3015
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- Histones are basic nuclear proteins that are responsiblefor the nucleosome structure of the chromosomal fiber ineukaryotes. Nucleosomes consist of approximately 146 bp of DNAwrapped around a histone octamer composed of pairs of each of thefour core histones (H2A, H2B, H3, and H4). The chromatin fiber isfurther compacted through the interaction of a linker histone, H1,with the DNA between the nucleosomes to form higher order chromatinstructures. This gene encodes a replication-independent member ofthe histone H2A family that is distinct from other members of thefamily. Studies in mice have shown that this particular histone isrequired for embryonic development and indicate that lack offunctional histone H2A leads to embryonic lethality. [provided byRefSeq].
- 1: Marques, M., et al. Epigenetics 5(4):267-272(2010)
- 2: Svotelis, A., et al. Cell Cycle 9(2):364-370(2010)
- 3: Thakar, A., et al. Biochemistry 48(46):10852-10857(2009)
- 4: Hardy, S., et al. PLoS Genet.(10), E1000687 (2009) :
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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$35 Dry Ice Shipment fee may be required on some items.
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