GTPase Activating Protein (phospho Ser387) Antibody
CATALOG NUMBER: 80-032- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Conjugate: Unconjugated
- Size: 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse, Rat
- IMMUNOGEN: GTPase Activating Protein (phospho Ser387) antibody was raised against a peptide sequence around phosphorylation site of serine 387 (R-I-S (p)-G-C) derived from Human GTPase Activating Protein.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: Western Blot: 1:500~1:1000
- SPECIFICITY: The antibody detects endogenous level of GTPase Activating Protein only when phosphorylated at serine 387.
- PREDICTED MOLECULAR WEIGHT: 72 kDa
Properties
- PURIFICATION: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: Store antibody at -20°C for up to one year.
Additional Info
- NCBI OFFICIAL SYMBOL: RACGAP1
- ADDITIONAL NAMES: GTPase activating protein, GTPase activating protein ID-GAP, RAC GTPase- activating protein 1, RACGAP1, RAC GTPase-activating protein
- Protein Accession Number: NP_001119575.1
- PROTEIN GI NUMBER: 21361397
- NCBI GENE ID NUMBER: 29127
Background
- Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation.
- 1: Doki N, et al. (2009)Cancer Sci 100, 1675-9. Minoshima Y, et al. (2003)Dev Cell 4, 549-60.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
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