Specifications
- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse
- IMMUNOGEN: Girdin (phospho Ser1417) antibody was raised against a peptide sequence around phosphorylation site of Serine 417 (L-E-M (p)-A-Q) derived from Human Girdin .
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: IHC
- SPECIFICITY: The antibody detects endogenous levels of Girdin only when phosphorylated at serine 1417.
- PREDICTED MOLECULAR WEIGHT: 216 kDa
Properties
- PURIFICATION: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: Store antibody at -20°C for up to one year.
Additional Info
- NCBI OFFICIAL SYMBOL: CCDC88A
- ADDITIONAL NAMES: APE, GIV, GRDN, HkRP1, KIAA1212
- Protein Accession Number: NP_060554.3
- PROTEIN GI NUMBER: 50897852
- NCBI GENE ID NUMBER: 55704
Background
- girdin IS a ubiquitously expressed actin binding protein that plays an important role in the formation of stress fibers and lamellipodia. Subsequent to phosphorylation by Akt, Girdin accumulates at the leading edge of migrating cells and appears to be crucial for the integrity of the actin cytoskeleton and for cell migration.
- 1: Enomoto A., Dev. Cell 9:389-402(2005).
- 2: Simpson F., Traffic 6:442-458(2005).
- 3: Hillier L.W., Nature 434:724-731(2005).
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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