GAB3 Antibody
CATALOG NUMBER: 58-446- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- IMMUNOGEN: This GAB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-58 amino acids from the N-terminal region of human GAB3.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
- PREDICTED MOLECULAR WEIGHT: 66 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: GAB3
- ADDITIONAL NAMES: GRB2-associated-binding protein 3, GRB2-associated binder 3, Growth factor receptor bound protein 2-associated protein 3, GAB3
- Protein Accession Number: Q8WWW8
- PROTEIN GI NUMBER: 74716251
- NCBI GENE ID NUMBER: 139716
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- GAB3 is a member of the GRB2-associated bindingprotein gene family. These proteins are scaffolding/dockingproteins that are involved in several growth factor and cytokinesignaling pathways, and they contain a pleckstrin homology domain,and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. Theprotein encoded by this gene facilitates macrophagedifferentiation. Two transcript variants encoding differentisoforms have been found for this gene.
- 1: Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
- 2: Davila, S., et al. Genes Immun. 11(3):232-238(2010)
- 3: Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
- 4: Barrett, J.C., et al. Nat. Genet. 41(6):703-707(2009)
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
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