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FZD6 (IN) Antibody
CATALOG NUMBER: 9551- Clonality: Polyclonal
- Tested Applications: E, IF, WB
- Host Species: Rabbit
- Species Reactivity: Human, Mouse, Rat
- Conjugate: Unconjugated
- Size: 0.02 mg | 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse, Rat
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Chimpanzee(100%); Monkey (100%); Dog (100%)
- IMMUNOGEN: Anti-FZD6 antibody (9551) was raised against a peptide corresponding to 14 amino acids in the central domain of human FZD6.
The immunogen is located within 50-550 amino acids of FZD6. - CONJUGATE: Unconjugated
- TESTED APPLICATIONS: E, IF, WB
- APPLICATION NOTE: WB: 2 μg/mL; IF: 10 μg/mL.
Antibody validated: Western Blot in human, mouse and rat samples; Immunofluorescence in human, mouse and rat samples. All other applications and species not yet tested. - POSITIVE CONTROL 1: Cat. No. 1219 - MCF-7 Cell Lysate
- POSITIVE CONTROL 2: Cat. No. 1282 - 3T3/NIH Cell Lysate
- PREDICTED MOLECULAR WEIGHT: Predicted: 79kD
Observed: 95 kD (Post-translational modification: 2 N-linked glycosylations)
Advanced Validation
- ISOFORMS: Human FZD6 has 2 isoforms, including isoform 1 (706aa, 79.3kD) and isoform 2 (674aa, 75.6kD). Mouse FZD6 has 1 isoform (709aa, 79kD). Rat FZD6 has one isoform (710aa, 79.1kD). 9551 can detect FZD6 in human, mouse and rat.
Properties
- PURIFICATION: FZD6 Antibody is affinity chromatography purified via peptide column.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: FZD6 Antibody is supplied in PBS containing 0.02% sodium azide.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: FZD6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: FZD6
- ADDITIONAL NAMES: FZD6 Antibody: Frizzled-6, Fz-6, hFz6
- Protein Accession Number: O60353
- PROTEIN GI NUMBER: 215273986
- NCBI GENE ID NUMBER: 8323
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- FZD6 Antibody: FZD6 acts as a receptor for Wnt proteins. Frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Together with FZD3, FZD6 is involved with neural tube closure and plays a role in the regulation of planar cell polarity, particularly in the orientation of asymmetric bundles of stereocilia on apical faces of a subset of sensory cells located in the inner ear.
- 1: Wang et al. J. Neurosci. 206;26(8):2147-2156
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
Note: Online orders only accepted for shipment within the USA. Click here for the list of international distributors.
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