Frizzled-10 / FZD10 Recombinant Protein
CATALOG NUMBER: 11-179- Tested Applications: WB
- Size: 0.1 mg
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- SPECIES: Human
- SOURCE SPECIES: HEK293 cells
- RECOMBINANT PROTEIN SEQUENCE: Ile 21 - Gly 161
- FUSION TAG: His Tag
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 18.0 kDa. The protein migrates as 22-25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- PREDICTED MOLECULAR WEIGHT: 18.0 kDa
Properties
- PURITY: >90% as determined by SDS-PAGE.
- PHYSICAL STATE: Lyophilized
- BUFFER: PBS, pH7.4
- STORAGE CONDITIONS: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Additional Info
- NCBI OFFICIAL SYMBOL: FZD10
- ADDITIONAL NAMES: Fz-10,FZD10,hFz10,FzE7,CD350
- Protein Accession Number: NP_009128.1
- NCBI GENE ID NUMBER: 11211
Background
- Frizzled-10 (FZD10) is also known as FzE7 or CD350, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD10 contains one FZ (frizzled) domain. FZD10 protein is a cell surface receptor, which is activated by Wnt proteins and involved in the regulation of cellular function. FZD10 interacts with WNT7B and MYOC.
- 1: Dorsam RT, Gutkind JS, Nat Rev Cancer. 2007 Feb; 7(2):79-94.
- 2: Wang, Z. et al. (2005) Mol. Cell. Biol. 25:5022.
- 3: Kwon HS, et al. Mol Cell Biol. 2009.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
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