FLIP Antibody [NF6]
CATALOG NUMBER: 36-162- Clonality: Monoclonal
- Tested Applications: ICC, IHC, WB
- Host Species: Mouse
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 100 ug
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- HOST SPECIES: Mouse
- SPECIES REACTIVITY: Human
- IMMUNOGEN: Recombinant human FLIP (aa 1-480).
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: ICC, IHC, WB
- APPLICATION NOTE: Immunohistochemistry (paraffin sections) . Western Blot (1:1000).
- SPECIFICITY: Recognizes short (FLIPS) and long (FLIPL) splice variants of human FLIP.
Properties
- CLONALITY: Monoclonal
- ISOTYPE: IgG1
- PHYSICAL STATE: Liquid
- BUFFER: Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
- CONCENTRATION: 1 mg/ml
- STORAGE CONDITIONS: Stable for at least 1 year after receipt when stored at -20°C.
Additional Info
- NCBI OFFICIAL SYMBOL: CFLAR
- ADDITIONAL NAMES: I-FLICE; CLARP; CASPER; Usurpin, CASH; FLAME-1
- Protein Accession Number: 2253679
- PROTEIN GI NUMBER: AAC51622
- NCBI GENE ID NUMBER: 8837
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- FLIP is an apoptosis regulator protein which functions as a crucial link between cell survival and cell death pathways in mammalian cells and acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. FLIP lacks enzymatic (caspase) activity. FLIP is highly expressed in skeletal muscle, pancreas, heart, kidney, placenta and peripheral blood leukocytes.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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$35 Dry Ice Shipment fee may be required on some items.
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