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Home / HEK293 cells / FITC-Labeled CD5 Recombinant Protein
FITC-Labeled CD5 Recombinant Protein
FITC-Labeled CD5 Recombinant Protein

FITC-Labeled CD5 Recombinant Protein

CATALOG NUMBER: 11-167
  • Tested Applications: WB

Specifications

  • SPECIES: Human
  • SOURCE SPECIES: HEK293 cells
  • RECOMBINANT PROTEIN SEQUENCE: Arg 25 - Pro 372
  • FUSION TAG: His Tag
  • TESTED APPLICATIONS: WB
  • APPLICATION NOTE: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 40.5 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
  • PREDICTED MOLECULAR WEIGHT: 40.5 kDa

Properties

  • PURITY: >95% as determined by SDS-PAGE.
  • PHYSICAL STATE: Lyophilized
  • BUFFER: PBS, pH7.4
  • STORAGE CONDITIONS: Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.

Additional Info

  • ADDITIONAL NAMES: CD5,LEU1

Background

  • T-cell surface glycoprotein CD5 is also known as Lymphocyte antigen T1/Leu-1 and LEU1,which is phosphorylated on tyrosine residues by LYN,so CD5 can create binding sites for PTPN6/SHP-1.CD5 may act as a receptor in regulating T-cell proliferation. CD5 is expressed at various developmental and activation stages on human B cells.CD5 is a well established negative regulator of TCR and BCR signalling.CD5-positive cells may also prevent the emergence of autoimmunity by provision of cytokines such as IL-10. Development,selection and function of different B- and T-cell subsets or their preferential survival may be directly or indirectly dependent on different glycan structures associated with CD5 or CD5-like molecules.
  • 1: van de Velde H., et al., 1991, Nature 351:662-665.
  • 2: Brill L.M., et al., 2004, Anal. Chem. 76:2763-2772.
  • 3: Rodamilans B., et al., 2007, J. Biol. Chem. 282:12669-12677.

Disclaimer

  • FOR RESEARCH USE ONLY
    For additional information, visit ProSci's Terms & Conditions Page.
  • Disclaimer: Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER: 11-167

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