FH Antibody
CATALOG NUMBER: 59-859- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Monkey, Mouse, Pig, Rat
- IMMUNOGEN: This FH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-135 amino acids from the N-terminal region of human FH.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
- PREDICTED MOLECULAR WEIGHT: 55 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: FH
- ADDITIONAL NAMES: Fumarate hydratase, mitochondrial, Fumarase, FH
- Protein Accession Number: P07954
- PROTEIN GI NUMBER: 1730117
- NCBI GENE ID NUMBER: 2271
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- The protein encoded by this gene is an enzymatic componentof the tricarboxylic acid (TCA) cycle, or Krebs cycle, andcatalyzes the formation of L-malate from fumarate. It exists inboth a cytosolic form and an N-terminal extended form, differingonly in the translation start site used. The N-terminal extendedform is targeted to the mitochondrion, where the removal of theextension generates the same form as in the cytoplasm. It issimilar to some thermostable class II fumarases and functions as ahomotetramer. Mutations in this gene can cause fumarase deficiencyand lead to progressive encephalopathy.
- 1: Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
- 2: Allegri, G., et al. J. Inherit. Metab. Dis. 33(4):411-419(2010)
- 3: Yogev, O., et al. PLoS Biol.(3), E1000328 (2010) :
- 4: Yang, Y., et al. Cancer Genet. Cytogenet. 196(1):45-55(2010)
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
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