FGFR1 Antibody
CATALOG NUMBER: 15-021- Clonality: Polyclonal
- Tested Applications: IF, IHC
- Host Species: Rabbit
- Species Reactivity: Human
- Conjugate: Unconjugated
- Size: 50 uL
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human
- IMMUNOGEN: Recombinant fusion protein containing a sequence corresponding to amino acids 22-290 of human FGFR1 (NP_075598.2).
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: IF, IHC
- APPLICATION NOTE: IHC: 1:50 - 1:200
IF: 1:50 - 1:200
Properties
- PURIFICATION: Affinity purification
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at -20°C. Avoid freeze / thaw cycles.
Additional Info
- NCBI OFFICIAL SYMBOL: FGFR1
- ADDITIONAL NAMES: FGFR1, soluble FGFR1 variant 2, soluble FGFR1 variant 1, proto-oncogene c-Fgr, OTTHUMP00000190880, OTTHUMP00000190876, OTTHUMP00000190875, OGD, N-SAM, KAL2, hydroxyaryl-protein kinase, heparin-binding growth factor receptor, HBGFR, fms-related tyrosine kinase 2, FMS-like tyrosine kinase 2, FLT-2, FLT2, FLJ99988, FLG, fibroblast growth factor receptor 1, FGFR-1, FGFBR, CEK, CD331, bFGF-R-1, BFGFR, basic fibroblast growth factor receptor 1
- NCBI GENE ID NUMBER: 2260
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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