FGFR1/2 (phospho Tyr463/466) Antibody
CATALOG NUMBER: 79-883- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Human, Mouse
- Conjugate: Unconjugated
- Size: 0.1 mg
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Human, Mouse
- IMMUNOGEN: FGFR1/2 (phospho Tyr463/466) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 463/466 (S-E-Y (p)-E-L) derived from Human FGFR1/2.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- SPECIFICITY: The antibody detects endogenous levels of FGFR1/2 only when phosphorylated at tyrosine 463/466.
- PREDICTED MOLECULAR WEIGHT: 91 kDa
Properties
- PURIFICATION: Antibodies were purified by affinity-chromatography using epitope-specific peptide.
- CLONALITY: Polyclonal
- ISOTYPE: IgG
- PHYSICAL STATE: Liquid
- BUFFER: Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
- CONCENTRATION: 1 mg/mL
- STORAGE CONDITIONS: Store antibody at -20°C for up to one year.
Additional Info
- NCBI OFFICIAL SYMBOL: FGFR1, FGFR2
- ADDITIONAL NAMES: BFGFR, CEK, FLG, CD331, FLT2
- Protein Accession Number: NP_075598.2
- PROTEIN GI NUMBER: 291327489
- NCBI GENE ID NUMBER: 2260;2263
Background
- The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation.
- 1: Itoh N., Biochem. Biophys. Res. Commun. 169:680-685(1990).
- 2: Dionne C.A., EMBO J. 9:2685-2692(1990).
- 3: Johnson D.E., Mol. Cell. Biol. 10:4728-4736(1990).
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
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