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- SPECIES: Murine
- SOURCE SPECIES: E. coli
- RECOMBINANT PROTEIN SEQUENCE: MFNLPLGNYK KPKLLYCSNG GHFLRILPDG TVDGTRDRSD QHIQLQLSAE SAGEVYIKGT ETGQYLAMDT EGLLYGSQTP NEECLFLERL EENHYNTYTS KKHAEKNWFV GLKKNGSCKR GPRTHYGQKA ILFLPLPVSS D
- BIOLOGICAL ACTIVITY: Assay 1: The ED50 was determined by the dose - dependent stimulation of thymidine uptake by 3T3 cells in the presence of heparin is ≤ 0.5 ng/mL corresponding to a specific activity of ≥ 2 x 106 units/mg.
Assay 2: The ED50 was determined by a cell proliferation assay using balb/c 3T3 cells is ≤ 0.2 ng/mL in the presence of 10 μg/mL heparin, corresponding to a specific activity of ≥ 5 x 106 units/mg.
Properties
- PURITY: Greater than 95% by SDS-PAGE gel and HPLC analyses.
Endotoxin level is less than 0.1 ng per μg (1EU/μg). - PHYSICAL STATE: Lyophilized
- STORAGE CONDITIONS: The lyophilized FGF acidic recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted FGF acidic is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing FGF acidic recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Additional Info
- NCBI OFFICIAL SYMBOL: Fgf1
- ADDITIONAL NAMES: Fam, Fgfa, Dffrx, Fgf-1, Fibroblast growth factor 1, Acidic fibroblast growth factor, FGF-1
- Protein Accession Number: NP_034327.1
- PROTEIN GI NUMBER: 6753850
- NCBI GENE ID NUMBER: 14164
Background
- FGF-acidic is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-acidic is a non-glycosylated heparin binding growth factor that is expressed in the brain, kidney, retina, smooth muscle cells, bone matrix, osteoblasts, astrocytes and endothelial cells. FGF-acidic has the ability to signal through all the FGF receptors. Recombinant murine FGF-acidic is a 15.9 kDa protein consisting of 141 amino acid residues.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: This product is for research use only.
Shipping Info
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