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- SPECIES: Human
- SOURCE SPECIES: HEK293 cells
- RECOMBINANT PROTEIN SEQUENCE: Human FGF-21 (aa 1-209) is fused at the C-terminus to the Fc portion of human IgG1.
- FUSION TAG: Fc Tag
- APPLICATION NOTE: This recombinant proteins is for research use only.
- BIOLOGICAL ACTIVITY: Activates ERK and FRS2alpha phosphorylation in bKlotho expressing cells.
Properties
- PURITY: >95% (SDS-PAGE).
Endotoxin level is less than 0.1EU/ μg purified protein (LAL test; Lonza). - PHYSICAL STATE: Liquid
- BUFFER: 0.2um-filtered solution in PBS.
- CONCENTRATION: ~1mg/ml
- STORAGE CONDITIONS: Working aliquots are stable for up to 3 months when stored at -20°C.
Additional Info
- NCBI OFFICIAL SYMBOL: FGF21
- ADDITIONAL NAMES: Fibroblast Growth Factor 21
- Protein Accession Number: Q9NSA1
- PROTEIN GI NUMBER: 9506597
- NCBI GENE ID NUMBER: 26291
Background
- FGF-21 (Fibroblast growth factor 21) stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of betaKlotho.
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.
Shipping Info
$65 Standard Overnight flat rate for as many products shipped within the United States.
$35 Dry Ice Shipment fee may be required on some items.
Note: Online orders only accepted for shipment within the USA. Click here for the list of international distributors.
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