FBXO8 Antibody
CATALOG NUMBER: 60-087- Clonality: Polyclonal
- Tested Applications: WB
- Host Species: Rabbit
- Species Reactivity: Mouse
- Conjugate: Unconjugated
- Size: 400 ul
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- HOST SPECIES: Rabbit
- SPECIES REACTIVITY: Mouse
- HOMOLOGY: Predicted species reactivity based on immunogen sequence: Bovine
- IMMUNOGEN: This FBXO8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-195 amino acids from the Central region of human FBXO8.
- CONJUGATE: Unconjugated
- TESTED APPLICATIONS: WB
- APPLICATION NOTE: For WB starting dilution is: 1:1000
- PREDICTED MOLECULAR WEIGHT: 37 kDa
Properties
- PURIFICATION: This antibody is purified through a protein A column, followed by peptide affinity purification.
- CLONALITY: Polyclonal
- ISOTYPE: Rabbit Ig
- PHYSICAL STATE: Liquid
- BUFFER: Supplied in PBS with 0.09% (W/V) sodium azide.
- CONCENTRATION: batch dependent
- STORAGE CONDITIONS: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Additional Info
- NCBI OFFICIAL SYMBOL: FBXO8
- ADDITIONAL NAMES: F-box only protein 8, F-box/SEC7 protein FBS, FBXO8, FBS, FBX8
- Protein Accession Number: Q9NRD0
- PROTEIN GI NUMBER: 13124142
- NCBI GENE ID NUMBER: 26269
- USER NOTE: Optimal dilutions for each application to be determined by the researcher.
Background
- This gene encodes a member of the F-box protein familywhich is characterized by an approximately 40 amino acid motif, theF-box. The F-box proteins constitute one of the four subunits ofthe ubiquitin protein ligase complex called SCFs(SKP1-cullin-F-box), which function in phosphorylation-dependentubiquitination. The F-box proteins are divided into 3 classes: Fbwscontaining WD-40 domains, Fbls containing leucine-rich repeats, andFbxs containing either different protein-protein interactionmodules or no recognizable motifs. The protein encoded by this genebelongs to the Fbxs class. It contains a C-terminal amino acidsequence that bears a significant similarity with a portion ofyeast Sec7p, a critical regulator of vesicular protein transport.This human protein may interact with ADP-ribosylationfactor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchangefactor) activity.
- 1: Cronin, S., et al. Eur. J. Hum. Genet. 17(2):213-218(2009)
- 2: Lamesch, P., et al. Genomics 89(3):307-315(2007)
- 3: Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
- 4: Ilyin, G.P., et al. Genomics 67(1):40-47(2000)
Disclaimer
- FOR RESEARCH USE ONLY
For additional information, visit ProSci's Terms & Conditions Page. - Disclaimer: Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Shipping Info
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